Cleaning temporary files
While it is running, a system creates temporary files. These are usually removed when they are no longer being used. Applications that terminate unexpectedly can cause files that are no longer needed to be left in folders. The Windows 'Disk Cleaner' can 'Clean Up' these folders by deleting files but it is rarely used. Scanning the folders where temporary files are stored can take time, but it is necessary as they can contain malware. This is why Spybot offers to clean up temporary folders.
Helpful Hint
If you have for some reason stored files that you want to retain in a temporary folder do not use this feature. Otherwise it is safe to use, since it will not delete files currently in use.