D.9 Keystrokes sent to the server wherever possible

In almost all cases, PuTTY sends keystrokes to the server. Even weird keystrokes that you think should be hot keys controlling PuTTY. Even Alt-F4 or Alt-Space, for example. If a keystroke has a well-defined escape sequence that it could usefully be sending to the server, then it should do so, or at the very least it should be configurably able to do so.

To unconditionally turn a key combination into a hot key to control PuTTY is almost always a design error. If a hot key is really truly required, then try to find a key combination for it which isn't already used in existing PuTTYs (either it sends nothing to the server, or it sends the same thing as some other combination). Even then, be prepared for the possibility that one day that key combination might end up being needed to send something to the server - so make sure that there's an alternative way to invoke whatever PuTTY feature it controls.