Disabling and Deleting Entries
If you don't want an entry to activate the next time you boot or login you can either disable or delete it. To disable an entry uncheck it. Autoruns will store the startup information in a backup location so that it can reactivate the entry when you recheck it. For items stored in startup folders Autoruns creates a subfolder named Autorunsdisabled. Check a disabled item to re-enable it.
You should delete items that you do not wish to ever execute. Do so by choosing Delete in the Entry menu. Only the currently selected item will be deleted.
If you are running Autoruns without administrative privileges on Windows Vista and attempt to change the state of a global entry, you'll be denied access. Autoruns will display a dialog with a button that enables you to re-launch Autoruns with administrative rights. You can also use the -e command-line option to launch initially launch Autoruns with administrative rights.